The science
Longevity has become one of the biggest buzzwords in wellness.
But behind the hype it's important to address the fact that longevity is not something that comes in a magic pill, injection, or biohack.
01 · Our philosophy
Healthy aging isn't governed by one biological pathway.
It's built on well-supported biology, interconnected systems working together, and consistent daily habits that add up over time.
That's the science-led philosophy behind Stay.
We purposefully formulated Stay to support the fundamental systems that influence how dogs feel, function, and age, from cellular energy and inflammatory balance to gut health, immune function, and mobility. Each ingredient was selected for its specific biological role and contribution to a more comprehensive approach to canine health.
- Cellular energy
- Inflammatory balance
- Gut health
- Immune function
- Mobility
Our goal is simple: To bring the breakthroughs transforming human longevity to the dogs we love like family.
02 · Our ingredients
Patented ingredients, backed by science
Melofeed®
Melofeed® is a patented, superoxide dismutase (SOD)-rich melon extract developed to support endogenous antioxidant defense systems. SOD is a critical antioxidant enzyme that catalyzes the conversion of superoxide radicals into hydrogen peroxide, which can then be neutralized by downstream antioxidant enzymes.
How it supports longevity?
Excessive reactive oxygen species (ROS) can damage mitochondrial membranes, proteins, and DNA, contributing to cellular dysfunction associated with aging. Supporting antioxidant defense and redox homeostasis may help preserve cellular integrity, mitochondrial function, and long-term tissue resilience.
TruMune® Pet
TruMune® Pet is a specialized postbiotic designed to support intestinal health and immune function. Its bioactive components interact with gut-associated lymphoid tissue (GALT), helping modulate innate immune responses and support intestinal barrier function.
How it supports longevity?
Age-related changes in the gut microbiome, intestinal barrier integrity, and immune regulation can contribute to chronic low-grade inflammation (inflammaging). Supporting gut–immune communication helps maintain immune homeostasis, metabolic resilience, and systemic health as dogs age.
OptiPEA®
OptiPEA® is a highly purified form of palmitoylethanolamide (PEA), an endogenous lipid mediator involved in inflammatory and discomfort-signaling pathways. PEA acts primarily through peroxisome proliferator-activated receptor alpha (PPAR-α), with beneficial effects on inflammatory signaling, mast-cell activity, and neuroimmune regulation.
How it supports longevity?
Dysregulated inflammatory and neuroimmune signaling can contribute to persistent discomfort and reduced mobility with age. By supporting pathways involved in inflammatory resolution and tissue homeostasis, PEA helps maintain physical resilience, functional mobility, and quality of life in aging dogs.
CurcuVET®
CurcuVET® is a bioavailability-enhanced curcumin formulation designed to support healthy inflammatory regulation. Curcumin has been studied for its ability to modulate NF-κB signaling, inflammatory mediators including COX-2, and oxidative stress pathways involved in joint and tissue health.
How it supports longevity?
Persistent activation of inflammatory pathways is a recognized hallmark of biological aging. Supporting inflammatory homeostasis helps protect connective tissues, maintain joint function, and reduce the impact of age-associated inflammatory stress on mobility and physical resilience.
Boswellia Extract
Boswellia extract is a botanical ingredient rich in boswellic acids, studied for their ability to regulate inflammatory pathways. These compounds help modulate the 5-LOX pathway and inflammatory mediators involved in joint discomfort, digestive inflammation, and organ tissues. By supporting a balanced inflammatory response, Boswellia can help maintain mobility, digestive comfort, and healthy organ function in dogs.
How it supports longevity?
Chronic, low-grade inflammation accelerates biological aging, affecting far more than your dog’s joints. It can disrupt gut health, weaken connective tissues, and place stress on vital organs. By helping regulate inflammatory pathways, Boswellia supports whole-body inflammatory balance, promoting mobility, digestive health, and long-term resilience as dogs age.
03 · Our key mechanism
Methylation: the cellular maintenance system.
- DNA Health
- Detoxification
- Organ Function
- Healthy Aging
Every day, your dog's body performs millions of biochemical reactions to produce energy, maintain healthy cells, process metabolic waste, and keep vital organs functioning.
Behind many of these processes is methylation, one of the body's most important biochemical maintenance systems.
Methylation helps regulate gene expression, supports DNA maintenance, and enables essential metabolic and detoxification pathways. As dogs age, changes in methylation patterns are closely associated with biological aging, making this process an important area of longevity research.
STAY combines four complementary nutrients to support this interconnected system:
TMG
Provides essential methyl groups that support SAMe production, healthy homocysteine metabolism, and liver function.
Glycine
Helps produce glutathione, the body's major intracellular antioxidant, while supporting liver detoxification and cellular protection.
Taurine
Supports liver health through bile acid conjugation, alongside mitochondrial function and metabolic resilience.
Niacinamide (Vitamin B3)
Supports NAD+ production, helping power cellular energy metabolism and the enzymes involved in DNA maintenance and repair.
04 · Why it matters
Why it matters for longevity.
Interesting fact: Age-related changes in DNA methylation are so closely associated with aging that scientists use them to develop epigenetic clocks that estimate biological age.
As dogs grow older, changes in DNA methylation, cellular metabolism, and the body's ability to manage oxidative stress can influence how effectively their biological systems function.
Methylation is particularly important because it helps regulate gene activity, maintain metabolic balance, kidney function, and support the liver's natural processing pathways.
By supporting methylation and its interconnected metabolic pathways, Stay helps nourish the cellular processes essential for organ health, metabolic resilience, and healthy aging.
Larissa Munoz
DVM + MBA | Veterinarian
Having reviewed the Stay formulation, I’m genuinely impressed by the thoughtful combination of science-backed ingredients and how the key mechanisms of action work together to support long-term health. It’s the kind of daily supplement I’d confidently recommend to help dogs stay active and healthy for years to come.
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Stay is more than a supplement company.
We're building a future where dogs don't simply live longer.
They live better for longer.
Where proactive care replaces reactive treatment.
Where science helps you enjoy more good years together with the dog you love like family.
Stay exists because dog years deserve an upgrade.
